Zoloft is known as a SSRI or serotonin reuptake inhibitor that can effectively treat patients that are experiencing depression symptoms like problems with sleeping, appetite changes, low energy levels, and low mood levels. Panic attacks, anxiety, unwanted thoughts, and levels of fear can be effectively reduced using this medication as a treatment option. It is important to speak with your physician about any drug interactions and side effects that may occur with the use of this type of antidepressant. Some of the most common side effects that some people experience include problems sleeping, nausea, stomach upset, dizziness, diarrhea, dry mouth, drowsiness, poor appetite, and increased sweating.