Two of the conditions that a large number of women face today that involves phases of the reproductive system would include PMS or premenstrual syndrome and PMDD that is otherwise known as premenstrual dysphoric disorder. The symptoms of these conditions will generally become noticeable during ovulation, which is a week prior to beginning the menstrual cycle for many women. Symptoms will generally worsen until the individual starts menstruating.

There are current studies that are being conducted to gain information as to how the increase and the decrease of estrogen and various other types of hormones that occurs during menstruation has an association with depression and brain chemistry changes that may occur during this time. A person should seek professional guidance and help when they first begin noticing that the symptoms of depression are becoming bothersome and having an effect on their daily life.